Natural compounds lower uric acid levels and hyperuricemia: Molecular mechanisms and prospective

Uric acid, hyperuricemia and vascular diseases.

Uric acid is the product of purine metabolism. It is known that hyperuricemia, defined as high levels of blood uric acid, is the major etiological factor of gout. A number of epidemiological reports have increasingly linked hyperuricemia with cardiovascular and neurological diseases. Studies highlighting the pathogenic mechanisms of uric acid point to an inflammatory response as the primary mec...

Hyperuricemia and increase in postsecretory reabsorption of uric acid.

M. Sanchez Bayle, Pediatric Nephrology Section, Hospital del Niño Jesus, Avda. Ménendez Pelayo, 65, E-28009 Madrid (Spain) Case 1 Case 2 Normal values1 Dear Sir, Fractional excretion of uric acid (FEUA) has been described as being derived from 4 different mechanisms: glomerular filtration, presecretory reabsorption, tubular secretion and postsecretory reabsorption [1]. Fractional excretion of u...

Chronic Hyperuricemia, Uric Acid Deposit and Cardiovascular Risk

Hyperuricemia is commonly associated with traditional risk factors such as dysglicemia, dyslipidemia, central obesity and abnormal blood pressure, i.e. the metabolic syndrome. Concordantly, recent studies have revived the controversy over the role of circulating uric acid, hyperuricemia, and gout as an independent prognostic factor for cardiovascular morbidity and mortality. In this regard, dif...

Studies on Uric Acid and Related Compounds

The systematic study of the substrate specificity of mammalian xanthine oxidase has indicated a common mechanism by which various purines may be dehydrogenated (1). The results obtained also made it clear why methylated xanthines, with the exception of 1-methylxanthine (2), cannot be oxidized by xanthine oxidase to the corresponding substituted uric acids (3, 4). Therefore, another source had t...

Anticancer Natural Compounds: Molecular Mechanisms and Functions. Part I